Coffee Cuts Liver Cancer Risk, Doesn't Help Colon, Studies Say

Feb. 15, 2005 (Bloomberg) -- Drinking coffee reduces the risk of developing liver cancer, though the beverage doesn't decrease chances of getting colorectal cancer, two studies found.

Japanese researchers studying more than 90,000 middle-aged men and women found that the risk of liver cancer for people who almost never drank coffee was about 547 cases per 100,000 people. The risk among those who drank coffee daily was about 215 cases per 100,000, according to the study.

A separate study from Brigham and Women's Hospital in Boston tracked about 134,000 men and women and found coffee had no significant effect on their risk of colorectal cancer. Both studies are to be published in the Feb. 16 edition of the Journal of the National Cancer Institute.

Karen Michels, an associate professor at Brigham and Women's who led the hospital's study, said researchers are just starting to get hard evidence on coffee's effects on various cancers. The medical community is interested in the findings because coffee- drinking is a widespread behavior that people can change, she said.

``You can study the genetic predispositions to different cancers, and it's interesting, but there's nothing can you do about it,'' Michels said in an interview. ``Coffee-drinking is a behavior, something you can modify.''

About 49 percent of Americans 18 years and older drink coffee daily, according to the National Coffee Association, based in New York. Japanese individuals drink an average of 10 cups of coffee a week, according to the study.

The Boston study specified that participants drank coffee with caffeine. The Japanese study didn't distinguish which type of coffee was consumed, though its authors said decaffeinated coffee is rarely drunk in Japan.

Inhibits Growths

Coffee contains a substance called chlorogenic acid, which has been shown to inhibit cancerous growths on the liver, according to the study led by Manami Inoue of the National Cancer Center in Tokyo.

Coffee with caffeine also was thought to help prevent colorectal cancer because it increases bowel function, which decreases damage to parts of the intestinal tract, Michels said.

``To our surprise, our study did not confirm that,'' Michels said.

The Brigham and Women's study found instead that decaffeinated coffee appeared to decrease the risk of colorectal cancer, Michels said. Decaf also increases bowel function, and doesn't contain caffeine, a substance some research has suggested may cause cancer, Michels said.

The medical community hasn't reached a consensus on how much coffee, if any, people should drink, and researchers are examining the beverage's effects on a variety of ailments, including stomach and esophageal cancers, heart disease and diabetes, Michels said.

To contact the reporter on this story:
Kevin Orland in Chicago at  korland@bloomberg.net.

To contact the editor responsible for this story:
Glenn Holdcraft at  gholdcraft@bloomberg.net.